Pinoresinol

SKU: orb1297240

Description

(+)-Pinoresinol is a bioactive lignan with documented anti-inflammatory, antioxidant, and cytoprotective properties. Research indicates it modulates key pathways including NF-κB and AP-1, upregulates p21, and has shown protective effects in models of cerebral ischemia-reperfusion and in C. elegans longevity studies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 487-36-5
• MW: 358.39
• Purity: 98.67% (May vary between batches)
• Formula: C₂₀H₂₂O₆
• SMILES: [H][C@]12CO[C@H](c3ccc(O)c(OC)c3)[C@@]1([H])CO[C@@H]2c1ccc(O)c(OC)c1
• Target: CDK|||p53|||Apoptosis|||NF-κB
• Solubility: DMSO:12 mg/mL (33.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.58 mM)

Bioactivity

• In Vitro:
  Six lignan standards [secoisolariciresinol diglucoside (SDG), secoisolariciresinol (SECO), Pinoresinol (PINO), lariciresinol, matairesinol (MAT), and hydroxymatairesinol] and their colonic metabolites [enterolactone (ENL) and enterodiol] were studied. First, differentiated cells were exposed to SDG, SECO, PINO, or ENL at increasing concentrations for 4 h, and their cellular contents (before and after deconjugation) were determined by HPLC. Second, in IL-1β-stimulated confluent and/or differentiated cells, lignan effects were tested on different soluble proinflammatory mediators quantified by enzyme immunoassays and on the NF-κB activation pathway by using cells transiently transfected. SECO, PINO, and ENL, but not SDG, were taken up and partly conjugated by cells, which is a saturable conjugation process. PINO was the most efficiently conjugated (75% of total in cells). In inflamed cells, PINO significantly reduced IL-6 by 65% and 30% in confluent and differentiated cells, respectively, and cyclooxygenase (COX)-2-derived prostaglandin E(2) by 62% in confluent cells. In contrast, MAT increased significantly COX-2-derived prostaglandin E(2) in confluent cells. Moreover, PINO dose-dependently decreased IL-6 and macrophage chemoattractant protein-1 secretions and NF-κB activity
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(+)-Pinoresinol, cancer, Apoptosis, apoptotic, CDK, caterpillar, NF-kB, NFkB, NFκB, NF-κB, p53, inhibit, lignol, Inhibitor, glioblastoma, Pinoresinol, sensitizer

Compound Identifiers

PubChem CID

73399