Pinocembrin

SKU: orb1222206

Description

Pinocembrin is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.(In Vitro):Pinocembrin (5, 10, 25, 50, 100 or 200 μM, 24 hours) significantly reduces cell viability of RBL-2H3 cells.Pinocembrin (25 or 50 μM) suppresses iNOS, PGE-2 and COX-2 levels, increases p38-Mapk and IкB-α, and inhibits phosphorylation of IкB-α.

Key Properties

• CAS Number: 480-39-7
• MW: 256.25
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₂O₄
• SMILES: C1[C@H](Oc2cc(cc(c2C1=O)O)O)c1ccccc1
• Target: NF-κB
• Solubility: DMSO : 125 mg/mL 487.80 mM

Bioactivity

• In Vitro:
  Pinocembrin (5, 10, 25, 50, 100 or 200 μM, 24 hours) significantly reduces cell viability of RBL-2H3 cells. Pinocembrin (25 or 50 μM) suppresses iNOS, PGE-2 and COX-2 levels, increases p38-Mapk and IкB-α, and inhibits phosphorylation of IкB-α. Cell Viability Assay Cell line: RBL-2H3 cells. Concentration: 5, 10, 25, 50, 100 or 200 μM. Incubation time: 24 hours. Result: Decreased cell viability by ~50% at ≥ 100 μM. Showed 75% cell viability at lower concentrations.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(+)-Pinocoembrin | Dihydrochrysin | Galangin flavanone

Quick Database Links

Gene Symbol

NF-κB