PIN1 inhibitor API-1

• Catalog Number: orb1307873
• Category: Small Molecules
• Description: PIN1 inhibitor API-1
• Purity: 98.48%
• MW: 366.3
• Biological Activity: PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
• CAS Number: 680622-70-2
• Formula: C₁₅H₁₃F₃N₆O₂
• SMILES: Nc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)c2[nH]cnc2n1
• Storage: -20°C
• Note: For research use only