PIN1 inhibitor API-1

SKU: orb1307873

Description

PIN1 inhibitor API-1

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 680622-70-2
• MW: 366.3
• Purity: 98.48%
• Formula: C₁₅H₁₃F₃N₆O₂
• SMILES: Nc1nc(OCc2ccc(CNC(=O)C(F)(F)F)cc2)c2[nH]cnc2n1
• Target: MicroRNA
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.65 mM);DMSO:250 mg/mL (682.5 mM)

Bioactivity

• Target IC50:
  Pin1:72.3 nM
• In Vivo:
  PIN1 inhibitor API-1 inhibits tumor growth by up-regulating mature miRNA biogenesis in mice .
• In Vitro:
  PIN1 inhibitor API-1 significantly suppresses SK-Hep-1, SNU-423, and Hep3B cell proliferation (IC50=0.683-4.16 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MicroRNA, miRNA, Inhibitor, inhibit, PIN1 inhibitor API 1, PIN1 inhibitor API1, PIN-1 inhibitor API-1, PIN1 inhibitor API-1, Pin1

Compound Identifiers

PubChem CID

29987694