Pimonidazole hydrochloride

SKU: orb1307875

Description

Pimonidazole hydrochloride is a hypoxia marker that selectively binds to macromolecules in hypoxic cells following nitroreduction. It is widely used in both in vivo and in vitro research for the qualitative and quantitative assessment of tumor hypoxia, often in conjunction with proliferation studies.

Key Properties

• CAS Number: 70132-51-3
• MW: 290.75
• Purity: >99.99% (May vary between batches)
• Formula: C₁₁H₁₉ClN₄O₃
• SMILES: Cl.OC(CN1CCCCC1)Cn1ccnc1[N+]([O-])=O
• Target: Others
• Solubility: H2O:30 mg/mL (103.18 mM)

Bioactivity

• In Vivo:
  Pimonidazole is a 2-nitroimidazole that is reductively activated specifically in hypoxic cells and forms stable adducts with thiol groups in proteins, peptides, and amino acids. Additionally, the amount of pimonidazole that is detected is directly proportional to the level of hypoxia within tumors in vivo.
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• In Vitro:
  Pimonidazole, the exogenous hypoxia marker, is a 2-nitroimidazole compound, which forms covalent bonds with cellular macromolecules at oxygen levels below 1.3%.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pimonidazole, Pimonidazole hydrochloride, Pimonidazole Hydrochloride, inhibit, Inhibitor

Compound Identifiers

PubChem CID

104997