PIM447

SKU: orb1708852

Description

PIM447 (LGH447) is an orally bioavailable, selective pan-PIM kinase inhibitor with demonstrated antitumor and bone-protective activity. It induces apoptosis and inhibits proliferation in hepatocellular carcinoma and multiple myeloma cell lines, supporting its use in oncology research for both in vitro and in vivo studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1210608-43-7
• MW: 440.46
• Purity: 98.97% (May vary between batches)
• Formula: C₂₄H₂₃F₃N₄O
• SMILES: FC1=C(N=C(C(NC=2C(=CC=NC2)[C@@H]3C[C@H](C)C[C@H](N)C3)=O)C=C1)C4=C(F)C=CC=C4F
• Target: Pim,Apoptosis
• Solubility: DMSO:80 mg/mL (181.63 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.35 mM)

Bioactivity

• Target IC50:
  Pim1:6 pM (Ki)|Pim2:18 pM (Ki)|Pim3:9 pM (Ki)
• In Vivo:
  PIM447 significantly reduced tumor load and prevented tumor-associated bone loss in a disseminated mouse model of human myeloma.
• In Vitro:
  HuH6 and COA67 cells were treated with PIM447 (0-20 μM, 72h), and the activity of PIM447 was significantly reduced with LD50 of 13 μM and 10 μM, respectively. Treatment with PIM447 (7.5 μM, 8h) resulted in increased apoptosis of HuH6 and COA67 cells. PIM447 (5 μM, 48h) reduced cancer cell dryness in HuH6 and COA67 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LGH 447, LGH447, LGH-447, PIM 447, PIM447, PIM-447

Compound Identifiers

PubChem CID

44814409