Pim-1 kinase inhibitor 8

SKU: orb2900398

Description

Pim-1 kinase inhibitor 8 (compound 12) is a potent inhibitor of Pim-1 kinase with an IC50 of 14.3 nM. Pim-1 kinase inhibitor 8 has potent cytotoxicity against MCF-7 and HepG2 cells with IC50s of 0.5 and 5.27 μM, respectively. Pim-1 kinase inhibitor 8 can used in study breast cancer.

Research Area

Pharmacology & Drug Discovery; Cell Biology

Images & Validation

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Key Properties

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CAS Number	916038-47-6
MW	275.3
Purity	>98% (HPLC)
Formula	C₁₄H₁₇N₃O₃
SMILES	N#CC1=C(N=C(C=C1C)C)OCC(=O)N2CCOCC2
Target	PKC
Solubility	In Vitro: DMSO : 125 mg/mL (454.05 mM; Ultrasonic )

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

PKC

Protocol Information

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Purity:	99.92% (May vary between batches)
CAS Number:	916038-47-6
MW:	275.3
Formula:	C₁₄H₁₇N₃O₃