Pilloin

SKU: orb1684314

Description

Pilloin is a selective ATP-competitive kinase inhibitor used as a research tool to study oncogenic signaling, inflammation, and metabolism. Its modulation of proliferation and apoptosis pathways supports both in vitro mechanistic studies and proof-of-concept research in preclinical animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 32174-62-2
• MW: 314.29
• Purity: 99.04% (May vary between batches)
• Formula: C₁₇H₁₄O₆
• SMILES: O=C1C=C(OC=2C=C(OC)C=C(O)C12)C=3C=CC(OC)=C(O)C3
• Target: ATPase
• Solubility: DMSO:24 mg/mL (76.36 mM)

Bioactivity

• In Vivo:
  Pilloin (10 mg/kg, i.p.) significantly reduced the expression levels of pro-inflammatory cytokines TNF-α and IL-6 in the serum of LPS-induced septic C57BL/6 male mice. At the same time, Pilloin also markedly inhibited IL-6 expression in multiple organs (liver, lung, spleen, and kidney).
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• In Vitro:
  Pilloin (3–30 μM, 1–24 hours) significantly inhibited the transcriptional activity of NF-κB and the phosphorylation of its upstream regulatory protein IκB in bacterial LPS-induced RAW 264.7 cells, while only causing slight cytotoxicity at 30 μM, with a cell survival rate of 85% .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Pilloin

Compound Identifiers

PubChem CID

5320496