Pikamilone

SKU: orb1225238

Description

Pikamilone is an intelligent medicine.

Key Properties

• CAS Number: 34562-97-5
• MW: 208.21
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₂N₂O₃
• SMILES: O=C(O)CCCNC(C1=CN=CC=C1)=O
• Target: Others
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  Animal model: Picrotoxin (HY-101391)-induced epilepsy model in rats. Dosage: 20 or 50 mg/kg. Administration: Intraperitoneal injection (i.p.). Result: Significantly decreased the frequency and duration of seizure spike-wave discharges (SWDs) in doses of 50 mg/kg. Decreased the intensity of SWDs in smaller doses (20 mg/kg). Animal model: Alloxan (HY-W017227)-induced diabetes mellitus model in rats. Dosage: 250 mg/ kg. Administration: Oral gavage (p.o.). Result: Suppressed NLRP3 activity, as indicated by a significant decrease in the area of immunopositive pancreatocytes to (21, 30 ± 5, 44) and (39, 31 ± 5, 24) %, respectively, relative to the value in the group of animals that were not treated (75, 19±7, 69%). Promoted correction of functional disorders of the pancreas during alloxan-induced diabetes mellitus by inhibiting activation of NLRP3 inflammasome in pancreatocytes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nicotinoyl-GABA | Nicotinoyl GABA | NicotinoylGABA | Pikamilon | Pikamilone

Quick Database Links

Gene Symbol

Others