PIK-294

SKU: orb1305765

Description

PIK-294 is a highly selective small molecule inhibitor of the PI3K p110δ isoform, exhibiting potent activity with an IC50 of 10 nM. It is a valuable research tool for studying PI3Kδ signaling in immunological and oncological contexts, applicable in both in vitro biochemical assays and in vivo disease models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 900185-02-6
• MW: 489.53
• Purity: >99.99% (May vary between batches)
• Formula: C₂₈H₂₃N₇O₂
• SMILES: Cc1ccccc1-n1c(Cn2nc(-c3cccc(O)c3)c3c(N)ncnc23)nc2cccc(C)c2c1=O
• Target: PI3K
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:91 mg/mL (185.89 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (6.74 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  p110β:490 nM|p110γ:160 nM|p110α:10 μM|p110δ:10 nM
• In Vivo:
  PIK-294 exhibits inhibitory effects on various PI3K isoforms, including p110β, p110δ, and p110γ; however, it demonstrates low selectivity towards p110α.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p110δ, p110γ, p110β, p110α, PI3K, PIK294, PIK-294, PIK 294, Phosphoinositide 3-kinase, Inhibitor, inhibit

Compound Identifiers

PubChem CID

24905149