PIK-108

SKU: orb1217504

Description

PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).

Key Properties

• CAS Number: 901398-68-3
• MW: 364.44
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₄N₂O₃
• SMILES: O=C1C=C(N2CCOCC2)OC3=C(C(NC4=CC=CC=C4)C)C=C(C)C=C13
• Target: PI3K
• Solubility: DMSO:45 mg/mL (123.48 mM; Need ultrasonic)

Bioactivity

• In Vitro:
  PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt. Western blot analysis. Cell line: Glioma cell lines expressing wild-type PTEN. Concentration: 0.1, 0.5, 1, 4, and 10 μM Incubation time: 1 hour. Result: Showed variable inhibition of PKB/Akt phosphorylation but exhibited a trend toward reducing PKB/Akt phosphorylation more effectively in mutant PTEN-expressing cell lines than in wild-type PTEN-expressing cell lines.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PIK 108 | PIK108

Quick Database Links

Gene Symbol

PI3K