Pifithrin-β hydrobromide

SKU: orb1224870

Description

A cyclic analog of Pifithrin-α and a small molecule inhibitor of p53; prevents dexamethasone-induced cell death in murine thymocytes with EC50 of 2.01 uM, sensitizes p53-deficient tumors to radiotherapy and chemotherapy and increases apoptosis in cancer cells.

Key Properties

• CAS Number: 511296-88-1
• MW: 349.2886
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₇BrN₂S
• SMILES: CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br
• Target: MDM2-p53
• Solubility: DMSO: 26 mg/mL

Bioactivity

• In Vitro:
  Pifithrin-α hydrobromide (PFT β hydrobromide), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclic Pifithrin-α hydrobromide | PFT-β hydrobromide

Quick Database Links

Gene Symbol

MDM2-p53