Picroside IV

SKU: orb1684315

Description

Picroside IV, a catalpol-derived iridoid glycoside from Picrorhiza scrophulariiflora, exhibits diverse pharmacological activities such as neuroprotection and anti-inflammatory effects. It is a valuable research compound for in vitro and in vivo studies in neuroscience, oncology, and metabolic disease research.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 211567-04-3
• MW: 508.47
• Formula: C₂₄H₂₈O₁₂
• SMILES: C(O)[C@@]12[C@@](O1)([C@@H](O)[C@]3([C@@]2([C@H](O[C@@H]4O[C@H](COC(/C=C/C5=CC=C(O)C=C5)=O)[C@@H](O)[C@H](O)[C@H]4O)OC=C3)[H])[H])[H]
• Target: Others
• Solubility: DMSO:80 mg/mL (157.33 mM)

Bioactivity

• In Vitro:
  The pharmacokinetic results indicated that the six components (picroside I, picroside II, vanillic acid, androsin, cinnamic acid, and Picroside IV) in TGPR could be quickly absorbed and slowly eliminated. Their bioavailability was less than 12.37%, indicating poor absorption after intragastric dosing. For tissue distribution, the six components in TGPR were detected in the liver, and only androsin could penetrate the blood-brain barrier. Meanwhile, the excretion study demonstrated that vanillic acid was mostly excreted as prototype drugs, and the remaining five components might be widely metabolized in vivo as the metabolites; the unconverted form was excreted mainly by the feces route .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Picroside IV

Compound Identifiers

PubChem CID

23928135