Picropodophyllin

SKU: orb1223118

Description

Picropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis.

Key Properties

• CAS Number: 477-47-4
• MW: 414.41
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₂O₈
• SMILES: COc1cc(cc(c1OC)OC)[C@H]1[C@H]2[C@H](COC2=O)[C@H](c2cc3c(cc12)OCO3)O
• Target: IGF-1R
• Solubility: DMSO : 50 mg/mL. 120.65 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AXL1717 | AXL-1717 | AXL 1717 | PPP | picropodophyllin

Quick Database Links

Gene Symbol

IGF-1R