PICK1 PDZ-IN-1

SKU: orb3174490

Description

PICK1 PDZ-IN-1 (Compound 6b) is a selective inhibitor of the protein kinase C binding protein 1 (PICK1 PDZ) domain that can cross the blood-brain barrier, with a Ki value of 27.73 μM. It competitively inhibits the interaction between PICK1 and the GluA2 subunit of AMPA receptors. This compound enhances the survival rate of glutamate-induced HT22 cells and primary cortical neuronal cells while inhibiting ROS production. PICK1 PDZ-IN-1 exhibits neuroprotective effects by reducing the area of cerebral infarction and is applicable in ischemic stroke research.

Key Properties

• Target: iGluR,PKC,ROS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

iGluR,PKC,ROS