PI5P4Ks-IN-2

SKU: orb1745169

Description

PI5P4Ks-IN-2 is a potent small molecule inhibitor targeting all PI5P4K isoforms, with IC50 values of <4.3 µM (α), <4.6 µM (β), 6.2 µM (γ), and 0.32 µM (γ+). It serves as a valuable research tool for investigating phosphoinositide signaling in cellular models and has been utilized in studies exploring metabolic regulation and cancer biology.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2766854-03-7
• MW: 357.45
• Purity: 99.35% (May vary between batches)
• Formula: C₂₂H₂₃N₅
• SMILES: N(CC1=CC=CC=N1)C2=C3C(=NC(=N2)C4=C(C(C)C)C=CC=C4)C=CN3C
• Target: PI3K
• Solubility: DMSO:27.5 mg/mL (76.93 mM)

Bioactivity

• Target IC50:
  PI5P4Kγ (WT):68 nM(Ki)|PI5P4Kβ:<4.6(pIC50)|PI5P4Kβ:＞30 μM(Ki)|PI5P4Kγ+:0.32(pIC50)|PI5P4Kγ:6.2(pIC50)|PI5P4Kα:<4.3(pIC50)
• In Vivo:
  PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).
  Read more...
• In Vitro:
  PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI5P4KsIN2, PI5P4Ks-IN-2, PI5P4Kγ

Compound Identifiers

PubChem CID

163321784