PI4KIIIbeta-IN-9

SKU: orb1309247

Description

PI4KIIIbeta-IN-9 is a highly potent and selective small molecule inhibitor of phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ), exhibiting an IC50 value of 7 nM. This compound is a valuable research tool for investigating PI4KIIIβ's role in intracellular signaling, viral replication, and lipid metabolism in both cellular and biochemical assays.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1429624-84-9
• MW: 487.59
• Purity: 98.22% (May vary between batches)
• Formula: C₂₃H₂₅N₃O₅S₂
• SMILES: COc1ccc(cc1S(=O)(=O)Nc1ccc(O)cc1)-c1sc(NC(=O)C2CCCC2)nc1C
• Target: PI4K|||PI3K
• Solubility: DMSO:4.88 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.05 mM)

Bioactivity

• Target IC50:
  PI3Kα:2 μM|PI4KIIIα:2.6 μM|PI4KIIIβ:7 nM|PI3Kγ:1046 nM|PI3KC2γ:1 μM|PI3Kδ:152 nM
• In Vitro:
  PI4KIIIbeta-IN-9 (Compound 9) exhibits weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~2 μM), and PI4KIIIα (~2.6 μM), with less than 50% inhibition up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. It conforms to the active site of PI4KIIIβ, forming extensive contacts, and inhibits PI3Kδ and PI3Kγ with IC50 values of 152 nM and 1046 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Phosphatidylinositol 4 kinases, Phosphoinositide 3-kinase, PI4 kinases, PI3Kδ, PI3Kγ, PI4KIIIβ, PI4KIIIβ-IN-9, PI4KIIIα, PI4KIIIbeta IN 9, PI4KIIIbetaIN9, PI-4KIIIbeta-IN-9, PI4KIIIbeta-IN-9, PI4KIIIb-IN-9, PI4K, PI3KC2γ, PI3Kα, PI3K

Compound Identifiers

PubChem CID

71533728