PI4KIIIbeta-IN-10

SKU: orb1309248

Description

PI4KIIIbeta-IN-10 is a highly potent and selective small molecule inhibitor of phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ), exhibiting an IC50 value of 3.6 nM. This inhibitor is a valuable research tool for studying phosphoinositide signaling in virology, autophagy, and intracellular trafficking through both in vitro biochemical and cellular assays.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1881233-39-1
• MW: 475.58
• Purity: 99.85%
• Formula: C₂₂H₂₅N₃O₅S₂
• SMILES: COc1ccc(cc1S(=O)(=O)Nc1ccc(O)cc1)-c1sc(NC(=O)C(C)(C)C)nc1C
• Target: PI4K,PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.21 mM);DMSO:30 mg/mL (63.08 mM)

Bioactivity

• Target IC50:
  PI3Kα:10 μM|PI4KIIIα:3 μM|PI3Kγ:20 μM|PI4KIIIβ:3.6 nM|PI3KC2γ:1 μM|PI3Kδ:720 nM
• In Vitro:
  The most potent of these molecules (PI4KIIIbeta-IN-10；compound 10) was screened over a panel of nine related lipid kinases and was >200 fold selective for PI4KIIIβ across all enzymes tested. Two of the most potent and selective molecules (compound 9+10) were also the most effective antiviral compounds in a cellular model of Hepatitis C virus replication, with the best balance of antiviral potency and low cellular toxicity. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3KC2γ, PI3Kα, PI3Kδ, PI3Kγ, PI4KIIIβ-IN-10, PI4KIIIα, PI4KIIIβ, PI4KIIIb-IN-10, PI4KIIIbeta IN 10, PI4KIIIbetaIN10, PI-4KIIIbeta-IN-10, PI4KIIIbeta-IN-10, PI4 kinases, PI4K, Phosphatidylinositol 4 kinases, inhibit, Inhibitor

Compound Identifiers

PubChem CID

71549093