PI4KIII beta inhibitor 5

SKU: orb3028611

Description

PI4KIII beta inhibitor 5 (Compound 43) is an inhibitor of PI4KIIIβ with an IC50 of 19 nM. By inhibiting the PI3K/AKT pathway, it induces apoptosis in cancer cells, causes cell cycle arrest at the G2/M phase, and promotes autophagy. Additionally, PI4KIII beta inhibitor 5 demonstrates significant anti-tumor activity in the H446 small cell lung cancer xenograft model. This compound is applicable in cancer research studies.

Research Area

Metabolism Research; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3029506-23-5
• MW: 523.616
• Formula: C₂₄H₂₇F₂N₃O₄S₂
• SMILES: O=C(NC1=NC(=C(S1)C=2C=CC(OC)=C(C2)S(=O)(=O)NCC3=CC=C(F)C=C3F)C)CCCCC
• Target: PI4K

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI4K