PI3K/mTOR Inhibitor-2

SKU: orb1309250

Description

PI3K/mTOR Inhibitor-2 is a potent dual-targeting agent, inhibiting PI3K isoforms (α, β, δ, γ) and mTOR with low nanomolar IC50 values. This compound demonstrates antitumor activity and is a valuable tool for investigating PI3K/mTOR signaling in cancer research, both in cellular and animal models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1848242-58-9
• MW: 478.86
• Purity: 99.54%
• Formula: C₂₀H₁₃ClF₂N₄O₄S
• SMILES: COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(Cl)c(=O)n2c1
• Target: PI3K,mTOR
• Solubility: DMSO:55 mg/mL (114.86 mM)

Bioactivity

• Target IC50:
  PI3Kδ:16 nM|mTOR:4.7 nM|PI3Kγ:1 nM|PI3Kβ:34 nM|PI3Kα:3.4 nM
• In Vivo:
  PI3K/mTOR Inhibitor-2 demonstrated in vivo efficacy in a PC-3M tumor xenograft model.
• In Vitro:
  PI3K/mTOR Inhibitor-2 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation with IC50s of 11.6 and 89.2 nM in cell assays, and good pharmacokinetic profile.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3Kβ, PI3Kγ, PI3Kδ, PI3K, PI3Kα, PI3K/mTOR Inhibitor2, PI-3K/mTOR Inhibitor-2, PI3K/mTOR Inhibitor-2, PI3K/mTOR Inhibitor 2, Phosphoinositide 3-kinase, Mammalian target of Rapamycin, Inhibitor, inhibit, mTOR

Compound Identifiers

PubChem CID

118616775