PI3K/mTOR Inhibitor-12

SKU: orb1744944

Description

PI3K/mTOR Inhibitor-12 is a potent, orally bioavailable small molecule with high selectivity, exhibiting IC50 values of 0.06 nM against PI3Kα and 3.12 nM against mTOR. It demonstrates significant antitumor efficacy in preclinical models, supported by in vitro cell proliferation assays and in vivo xenograft studies, while showing a favorable toxicity profile with reduced liver toxicity.

Research Area

Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2891692-83-2
• MW: 611.62
• Formula: C₂₇H₂₇F₂N₉O₄S
• SMILES: COC1=C(C=C(C=N1)C2=NN3C(=NC=C3C4=CN(N=N4)CCCN5CCOCC5)C=C2)NS(=O)(=O)C6=C(C=C(C=C6)F)F
• Target: mTOR,PI3K

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166642421