PI3Kα/mTOR-IN-1

SKU: orb1708779

Description

PI3Kα/mTOR-IN-1 is a potent dual inhibitor with low nanomolar activity, exhibiting a cell-free assay Kᵢ of 10.6 nM for PI3Kα and 12.5 nM for mTOR. This compound is a valuable chemical tool for studying PI3K/mTOR signaling in cancer research and for conducting both in vitro and in vivo experimental models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1013098-90-2
• MW: 310.35
• Purity: 99.30% (May vary between batches)
• Formula: C₁₆H₁₈N₆O
• SMILES: O=C1N(C=2C(C=C1C=3C=NNC3)=C(C)N=C(N)N2)C4CCCC4
• Target: PI3K,mTOR
• Solubility: DMSO:11 mg/mL (35.44 mM)

Bioactivity

• Target IC50:
  mTOR:10.6 nM (ki)|PI3Kα:12.5 nM (ki)|PI3Kα:7 nM (Cell Assay)
• In Vivo:
  PI3Kα/mTOR-IN-1 exhibited exhibited moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability.
• In Vitro:
  PI3Kα/mTOR-IN-1 exhibited excellent kinase selectivity from Pfizer’s in-house kinase selectivity panel of 43 kinases.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, PI-3Kα/mTOR-IN-1, PI3Kα/mTOR-IN-1, PI3Kalpha/mTOR-IN-1, PI3Ka/mTOR-IN-1, PI3Kα, PI3Kα/mTOR IN 1, PI3Kα/mTORIN1

Compound Identifiers

PubChem CID

59258964