PI3Kδ/HDAC6-IN-1

SKU: orb3135950

Description

PI3Kδ/HDAC6-IN-1 (Compound 22E) is an orally active dual inhibitor of PI3Kδ and HDAC6, with IC50 values of 2.4 nM and 6.2 nM, respectively. It exhibits potent antiproliferative effects against non-Hodgkin's lymphoma (NHL) cells and demonstrates antitumor activity in vivo without significant toxicity. PI3Kδ/HDAC6-IN-1 induces cell cycle arrest at the G0/G1 phase and triggers apoptosis. Additionally, it inhibits the PI3K/AKT/mTOR signaling pathway and enhances the acetylation levels of α-tubulin and histone H3.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 3075011-99-0
• MW: 650.73
• Formula: C₃₄H₃₈N₁₀O₄
• SMILES: C(C)C=1N(C=2C(N1)=CC=CC2)C3=NC(=C4C(=N3)N(C)C(CN5C(=O)CN(CC6=CC=C(/C=C/C(NO)=O)C=C6)CC5)=N4)N7CCOCC7
• Target: Histone Methyltransferase,Microtubule Associated,Bcl-2 Family,ROS,PI3K,Apoptosis,Caspase,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histone Methyltransferase,Microtubule Associated,Bcl-2 Family,ROS,PI3K,Apoptosis,Caspase,HDAC