PI3K/HDAC-IN-3

SKU: orb2565530

Description

PI3K/HDAC-IN-3 (36) is a potent dual inhibitor of PI3Kα (IC50=0.23 nM) and HDAC1 (IC50=172 nM). It reduces p-AKT and increases acetyl-H3 in MV4-11 cells and shows dose-dependent antitumor efficacy in MV4-11 xenograft models, supporting its use in oncology research for hematological malignancies.

Research Area

Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 3006905-22-9
• MW: 676.73
• Formula: C₃₄H₃₄F₂N₆O₅S
• SMILES: O(CCCCCCC(NC1=C(N)C=CC=C1)=O)C=2C3=C(C=C(C2)C=4C=C(NS(=O)(=O)C5=C(F)C=C(F)C=C5)C(OC)=NC4)C(C)=NC=N3
• Target: PI3K,HDAC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

169494474