PI3KC2γ-IN-1

SKU: orb3173540

Description

PI3KC2γ-IN-1 (Compound 23) is an orally active and selective inhibitor of PI3KC2γ with an IC50 of 4 nM. It downregulates the Akt2-glycogen synthase (GS) signaling pathway, ultimately inhibiting the conversion of glucose to glycogen and reducing excessive glycogen accumulation in the liver. PI3KC2γ-IN-1 significantly inhibits insulin-induced accumulation of PI(3,4)P2 in primary hepatocytes and HepG2 liver cancer cells. It is useful for researching glycogen storage diseases (GSDs).

Research Area

Signal Transduction

Key Properties

• Target: PI3K

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K