PI3Kα-IN-9

SKU: orb1688382

Description

PI3Kα-IN-9

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2715287-67-3
• MW: 383.4
• Purity: 98.41% (May vary between batches)
• Formula: C₁₈H₂₁N₇O₃
• SMILES: N1=C(N=C(N=C1N2CCOCC2)N3CCOCC3)C4=CC=C5OC(=NC5=C4)N
• Target: Apoptosis,PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.61 mM);DMSO:80 mg/mL (208.66 mM)

Bioactivity

• Target IC50:
  PI3Kδ:146 nM|PI3Kβ:153 nM|PI3Kα:4.4 nM|PI3Kγ:128 nM
• In Vivo:
  In male Sprague-Dawley rats, PI3Kα-IN-9 (1 and 10 mg/kg; oral administration and intravenous injection; for 24 hours) demonstrated favorable pharmacokinetic parameters in vivo.
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• In Vitro:
  PI3Kα-IN-9 (0-2 μM; 72 hours) inhibited the growth of various cancer cells with IC50 values ranging from 0.43 to 1.33 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, PI3Kα

Compound Identifiers

PubChem CID

164886635