PI3K-IN-58

SKU: orb3027747

Description

PI3K-IN-58 (Compound 17f) is an inhibitor of PI3Kα with an IC50 value of 0.039 μM. It shows significant antiproliferative effects on PC-3, 22RV1, MDA-MB-231, and MDA-MB-453 cell lines with IC50 values of 3.48 μM, 1.06 μM, 2.21 μM, and 0.93 μM, respectively. PI3K-IN-58 induces apoptosis by downregulating the expression of anti-apoptotic proteins Bcl-XL and Bcl-2 while upregulating the expression of the pro-apoptotic protein BAX. This compound is applicable for research in cancer targeting through PI3K pathways.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3067572-78-2
• MW: 450.51
• Formula: C₂₂H₂₂N₆O₃S
• SMILES: C(=C/C(NCCO)=O)\C=1SC2=C(N=C(N=C2C1)C3=C4C(=CC=C3)NN=C4)N5CCOCC5
• Target: PI3K,Apoptosis,Bcl-2 Family

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,Apoptosis,Bcl-2 Family