PI3Kα-IN-29

SKU: orb3174480

Description

PI3Kα-IN-29 is an efficacious, orally bioavailable, and selective PI3Kα inhibitor with an IC50 value of 2.5 nM. It demonstrates over 400-fold selectivity against PI3Kβ/δ/γ/mTOR. This compound selectively degrades the H1047R mutant p110α protein and inhibits PI3Kα kinase activity. PI3Kα-IN-29 suppresses the PI3K/AKT/mTOR signaling pathway, induces G1 phase arrest, and inhibits cell migration. Additionally, it impedes tumor growth in T47 mouse models and is applicable for breast cancer research.

Research Area

Cell Biology, Signal Transduction

Key Properties

• Target: mTOR,CDK,Akt,PI3K,Cadherin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

mTOR,CDK,Akt,PI3K,Cadherin