PI3Kα-IN-27

SKU: orb3173748

Description

PI3Kα-IN-27 (Compound 50b) is an orally active PI3K-α inhibitor with an IC50 of 40 nM. It effectively inhibits PAK3, p110α, phosphorylated mTOR, and phosphorylated ERK1/2. PI3Kα-IN-27 can induce early apoptosis (Apoptosis) and demonstrates anticancer activity against pancreatic, lung, and breast cancers.

Key Properties

• CAS Number: 2098649-83-1
• MW: 466.6
• Formula: C₂₄H₃₀N₆O₂S
• SMILES: O=C(NC1=CC=C(C=C1)CC)NC2CCN(C3=NC=4C=CSC4C(=N3)N5CCOCC5)CC2
• Target: PI3K,PERK,mTOR,Apoptosis,PAK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PI3K,PERK,mTOR,Apoptosis,PAK