PI3Kα-IN-22

SKU: orb2565520

Description

PI3Kα-IN-22 (Compound 17) is a potent, selective, and orally bioavailable inhibitor specifically targeting the oncogenic PI3Kα H1047R mutant. With an IC50 of 1 nM in cellular assays, it has shown promising antitumor efficacy, including tumor regression in the HCC1954 xenograft model, supporting its use in cancer research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2925030-26-6
• MW: 467.47
• Formula: C₂₄H₂₃F₂N₅O₃
• SMILES: [C@@H](NC1=C(C(O)=O)C=CC=C1)(C)C=2C=3N(C(=O)C(C#N)=C(N3)N4CCC(F)(F)CC4)C=C(C)C2
• Target: PI3K

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168255584