PI3Kδ-IN-15

SKU: orb1298744

Description

PI3Kδ-IN-15 is a potent and selective small molecule inhibitor of phosphoinositide 3-kinase delta (PI3Kδ), exhibiting over 30-fold selectivity against the α, β, and γ isoforms. This selectivity makes it a valuable research tool for studying PI3Kδ-dependent signaling in immunological and oncological contexts, applicable in both cellular and animal models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1146702-54-6
• MW: 401.4
• Formula: C₂₁H₁₆FN₇O
• SMILES: [C@H](NC1=C2C(N=CN2)=NC=N1)(C)C=3N(C(=O)C=4C(N3)=CC=CC4F)C5=CC=CC=C5
• Target: PI3K
• Solubility: DMSO:25 mg/mL (62.28 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.98 mM)

Bioactivity

• Target IC50:
  p110β:565 nM|p110δ (Cell-free assay):2.5 nM|p110γ (Cell-free assay):89 nM|p110α:820 nM|hVps34:978 nM|DNA-PK:6729 nM
• In Vitro:
  PI3Kδ-IN-15 exhibited excellent efficiencies with sub-nanomolar functional potency when compared with the reference PI3Kδ inhibitor. PI3Kδ IC50 = 0.5 nM, PI3KγIC50 = 15.3 nM, PI3KβIC50 = 145 nM, and PI3KαIC50 = 152 nM.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GS 1101, GS1101, GS-1101, Idelalisib, CAL 101, CAL101, CAL-101, 1146702-54-6, (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one, Desmethyl Idelalisib, PI3Kδ, p110δ

Compound Identifiers

PubChem CID

118044236