PI3Kδ-IN-1

SKU: orb1708862

Description

PI3Kδ-IN-1 is a potent and selective small molecule inhibitor of the delta isoform of phosphoinositide 3-kinase, demonstrating an IC50 of 1.7 nM. It is a valuable research tool for studying PI3Kδ signaling in immunological and oncological contexts, applicable in both cellular and animal models of disease.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1911564-39-0
• MW: 471.44
• Purity: 99.85% (May vary between batches)
• Formula: C₂₂H₂₀F₃N₇O₂
• SMILES: CC(=O)N1CCN(C(=O)C1(C)C)c1cc(ccc1C#N)-c1cc(c2c(N)ncnn12)C(F)(F)F
• Target: PI3K
• Solubility: H2O:18 mg/mL (38.18 mM)

Bioactivity

• Target IC50:
  PI3Kδ:1.7 nM
• In Vivo:
  PI3Kδ-IN-1 shows greater than 50% suppression of paw swelling in mice. PI3Kδ-IN-1 has an EC50 of 10 nM at 24 h (ED50 of ∼1.25 mg/kg) in mice.
• In Vitro:
  PI3Kδ-IN-1 has an improved human/rodent in vitro stability correlation and a good permeability profile.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3KδIN1, PI-3Kδ-IN-1, PI3Kδ-IN-1, PI3Kδ, PI3Kδ IN 1, PI3Kdelta-IN-1

Compound Identifiers

PubChem CID

132220479