PI-3065

SKU: orb1223526

Description

A potent inhibitor of PI3K p110δ with IC50/Ki values of 5/1.5 nM respectively; exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM.

Key Properties

• CAS Number: 955977-50-1
• MW: 506.638
• Purity: >98% (HPLC)
• Formula: C₂₇H₃₁FN₆OS
• SMILES: FC1=C(C2=NC(N3CCOCC3)=C4C(C=C(CN5CCN(CC6CC6)CC5)S4)=N2)C7=C(NC=C7)C=C1
• Target: PI3K
• Solubility: DMSO

Bioactivity

• In Vivo:
  PI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss.
• In Vitro:
  PI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PI3065 | PI 3065

Quick Database Links

Gene Symbol

PI3K