PHTPP-1304

SKU: orb2646055

Description

PHTPP-1304 is an AUTOTAC-based small molecule that potently degrades ERβ (DC50 ~2 nM) by inducing p62 self-oligomerization and forming p62/ERβ puncta to engage autophagy. This compound is a valuable chemical probe for studying targeted protein degradation and autophagic flux in cellular models of cancer and endocrine research.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2410081-60-4
• MW: 944.96
• Formula: C₅₁H₅₀F₆N₄O₇
• SMILES: C(F)(F)(F)C=1N2C(=C(C(=N2)C3=CC=CC=C3)C4=CC=C(OCCOCCOCCNC[C@H](COC5=CC(OCCCC6=CC=CC=C6)=C(OCC7=CC=CC=C7)C=C5)O)C=C4)N=C(C(F)(F)F)C1
• Target: AUTACs,Autophagy,Estrogen Receptor/ERR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

153397130