Phototrexate

SKU: orb1690094

Description

Phototrexate is a photoswitchable methotrexate analog that acts as a potent inhibitor of human DHFR. Its antifolate activity is activated to a cis-form (IC50 = 6 nM) by 375 nm UVA light and deactivated to a trans-form by blue light or thermally. This enables precise, light-controlled modulation of cell proliferation in cancer research models like HeLa cells.

Research Area

Cell Biology, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 2268033-83-4
• MW: 437.41
• Formula: C₂₀H₁₉N₇O₅
• SMILES: NC=1C2=C(C=CC(/N=N/C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=C2)N=C(N)N1
• Target: DHFR,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

142608675