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Phosphodiesterase-IN-5

SKU: orb3173903

Description

Phosphodiesterase-IN-5 is a potent and orally bioavailable selective phosphodiesterase 10A (PDE10A) inhibitor, with an IC50 value of 6.2 nM. It demonstrates over 1612-fold selectivity for other PDE subtypes. By blocking the cAMP/PKA/CREB signaling pathway, it inhibits myofibroblast differentiation and shows significant antifibrotic effects in a Bleomycin (BLM)-induced mouse model of pulmonary fibrosis (PF). Phosphodiesterase-IN-5 is applicable for pulmonary fibrosis research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

TargetInterleukin,PKA,TNF,PDE

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Protocol Information