Phloretin

SKU: orb1304838

Description

Phloretin (NSC-407292) is a natural dihydrochalcone and a potent inhibitor of eukaryotic urea transporters, notably blocking VacA-mediated transport. It exhibits strong antioxidative properties and has demonstrated in vitro efficacy in inhibiting proliferation and inducing apoptosis in various cancer cell lines, including B16 melanoma and HL60 leukemia cells.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 60-82-2
• MW: 274.27
• Purity: >99.99% (May vary between batches)
• Formula: C₁₅H₁₄O₅
• SMILES: C(CCC1=CC=C(O)C=C1)(=O)C2=C(O)C=C(O)C=C2O
• Target: Endogenous Metabolite,Urea Transporter,SGLT,transporter
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (12.03 mM);Ethanol:48 mg/mL (175.01 mM);DMSO:80 mg/mL (291.68 mM)

Bioactivity

• In Vitro:
  Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dihydronaringenin, NSC407292, NSC-407292, NSC 407292, inhibit, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, GLUT, Glucose transporter, Sodium-dependent glucose cotransporters, RJC 02792, RJC02792, RJC-02792, Phloretin, SGLT1, SGLT, SGLT2

Compound Identifiers

PubChem CID

4788