PhiKan 083

SKU: orb1307883

Description

PhiKan 083 is a small molecule carbazole-based compound utilized in research. It serves as a tool compound for investigating protein aggregation pathways, particularly in cellular and biochemical assays related to neurodegenerative disease models.

Research Area

Cell Biology

Key Properties

• CAS Number: 880813-36-5
• MW: 238.33
• Purity: 98.20%
• Formula: C₁₆H₁₈N₂
• SMILES: CCn1c2ccccc2c2cc(CNC)ccc12
• Target: p53,MDM-2/p53,Mdm2
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (16.78 mM);DMSO:115 mg/mL (482.52 mM);Ethanol:100 mg/mL (419.59 mM)

Bioactivity

• Target IC50:
  p53-Y220C (Ln229 cells):150 μM(Kd) |p53-Y220C:167 μM(Kd)
• In Vitro:
  PhiKan 083 reduces the cell viability of engineered variants of Ln229 cells, in conbination with NSC 123127 (1 μM) enhances the pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, MDM-2/p53, inhibit, p53/MDM2, PhiKan 083, PhiKan083, PhiKan-083

Compound Identifiers

PubChem CID

4722579