PHGDH-IN-3

SKU: orb2900558

Description

PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2893778-31-7
• MW: 495.55
• Purity: >98% (HPLC)
• Formula: C₂₄H₁₈FN₃O₄S₂
• SMILES: N(C(=O)C1=CC=C(S(NC2=CC(C(C)=O)=CC=C2)(=O)=O)C=C1)C3=NC(=CS3)C4=CC(F)=CC=C4
• Target: Dehydrogenase
• Solubility: In Vitro: DMSO : 100 mg/mL (201.80 mM; Ultrasonic (<70°C)

Bioactivity

• In Vivo:
  Animal model: Balb/c nude mice. Dosage: 12.5, 25, 50 mg/kg. Administration: Intraperitoneal (i.p.); once daily for consecutive 31 days. Result: Exhibited an In vivo anti-tumor effect and significantly delayed the tumor growth. Significantly abated the tumor weights of mice at 25 mg/ kg.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Dehydrogenase