Pheophorbide a

SKU: orb1693745

Description

Pheophorbide A is a photosensitizer employed in photodynamic therapy (PDT) research, demonstrating antitumor, antioxidant, and anti-inflammatory properties. Its applications extend to studies in cancer, diabetes, and lymphatic function, utilizing both in vivo and in vitro experimental models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 15664-29-6
• MW: 592.68
• Purity: 99.99% (May vary between batches)
• Formula: C₃₅H₃₆N₄O₅
• SMILES: CCc1c(C)\c2=C\c3[nH]c(\C=C4/N=C([C@@H](CCC(O)=O)[C@@H]4C)C4=C5NC(\C=c1/[nH]2)C(C)=C5C(=O)[C@@H]4C(=O)OC)c(C)c3C=C
• Target: Antioxidant,Apoptosis,Photosensitizer
• Solubility: DMSO:PBS(pH 7.2) (1:3):0.25 mg/mL (0.42 mM);DMF:1 mg/mL (1.69 mM);DMSO:1 mg/mL (1.69 mM);Methanol:< 1 mg/mL (Insoluble)

Bioactivity

• In Vivo:
  In male immunocompetent C3H mice ( six-week-old, inoculated subcutaneously with AT-84 cells ), Pheophorbide A ( 10 mg / kg intravenous ( i.v. ) or a 30 mg / kg intraperitoneal ( i.p. ) injection ; after 24 h) significantly inhibited tumor growth up to 70 %。
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• In Vitro:
  Pheophorbide A significantly inhibited the growth of Hep3B cells with an IC50 value of 1.5 μM. The intracellular ROS level was increased in the cells treated with Pa-PDT, and the cytotoxic effect could be reversed when ascorbic acid was applied.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Antioxidant, Pheophorbide a

Compound Identifiers

PubChem CID

154809593