Phentolamine mesilate

SKU: orb1224335

Description

Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist.(In Vitro):Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively.Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively.Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) signi cantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner.Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs.(In Vivo):Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats.

Key Properties

• CAS Number: 65-28-1
• MW: 377.46
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₉N₃O·CH₄O₃S
• SMILES: CS(O)(=O)=O.CC1=CC=C(C=C1)N(CC1=NCCN1)C1=CC(O)=CC=C1
• Target: Adrenergic Receptor
• Solubility: Ethanol: 76 mg/mL (201.34 mM); Water: 76 mg/mL (201.34 mM); DMSO: 76 mg/mL (201.34 mM)

Bioactivity

• In Vivo:
  Phentolamine (1 mg/kg; i. v.) produces hypotension and tachycardia in rats.
• In Vitro:
  Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively. Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively. Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) significantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner. Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Regitine | Vasomax

Quick Database Links

Gene Symbol

Adrenergic Receptor