Pheniramine maleate

SKU: orb1310681

Description

Pheniramine maleate is an alkylamine-based H1 receptor antagonist that inhibits phospholipase A2 and suppresses nitric oxide production. It is used in research to study allergic responses, inflammation, and vascular tone in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 132-20-7
• MW: 356.42
• Purity: 99.85% (May vary between batches)
• Formula: C₁₆H₂₀N₂·C₄H₄O₄
• SMILES: CN(C)CCC(c1ccccc1)c1ccccn1.C(=C\C(=O)O)\C(=O)O
• Target: 5-HT Receptor,Histamine Receptor,Apoptosis
• Solubility: Ethanol:66 mg/mL (185.17 mM);H2O:65 mg/mL (182.37 mM);DMSO:40 mg/mL (112.23 mM)

Bioactivity

• Target IC50:
  H1 Receptor:1.01 mM
• In Vivo:
  Pheniramine maleate binds to histamine H1 receptors, which inhibits the production of phospholipase A2 and the endothelium-derived relaxing factor NO. This leads to a reduction in the activation of guanylate cyclase due to NO deficiency, resulting in decreased levels of cyclic GMP (cGMP). Consequently, this suppresses the contraction of smooth muscle tissues, reduces capillary permeability, and diminishes histamine-induced allergic responses.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

spinal block, Prophenpyridamine, sedative, Pheniramine, Pheniramine Maleate, Pheniramine maleate, Tripoton, Trimetose, Jurkat ALL, inhibit, lumbar puncture, HistamineReceptor, Histamine Receptor, Inhibitor, hypnotic, Inhiston, human T-cell acute lymphoblastic leukemia, HT, first-generation, CCRF-CEM, CNS, central nervous system, Daneral, 5HTReceptor, 5HT Receptor, antiemetic, Apoptosis, antipruritic, BC3H-1, Ca2+ influx

Compound Identifiers

PubChem CID

5282139