Phenformin hydrochloride

SKU: orb1308576

Description

Phenformin hydrochloride is a biguanide antidiabetic compound with antihyperglycemic properties. It is widely used in research to study metabolic disorders, cancer metabolism, and aging, employing both in vitro cell-based assays and in vivo animal models to investigate its mechanisms of action.

Research Area

Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 834-28-6
• MW: 241.72
• Purity: 97.11% (May vary between batches)
• Formula: C₁₀H₁₆ClN₅
• SMILES: Cl.NC(=N)NC(=N)NCCc1ccccc1
• Target: AMPK,Potassium Channel,Autophagy
• Solubility: DMSO:60 mg/mL (248.22 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (4.14 mM);H2O:44 mg/mL (182.03 mM);Ethanol:10 mg/mL (41.37 mM)

Bioactivity

• In Vivo:
  In H441 cells, phenformin increased AMPK activity while decreasing basal ion transport. In isolated hearts, Phenformin increased AMPK activity and phosphorylation. Phenformin significantly induced apoptosis in LKB1-deficient NSCLC cell lines.
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• In Vitro:
  In H441 cells, phenformin increased AMPK activity while decreasing basal ion transport. In isolated hearts, Phenformin increased AMPK activity and phosphorylation. Phenformin significantly induced apoptosis in LKB1-deficient NSCLC cell lines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phenformin hydrochloride, Phenformin, Phenformin HCl, Phenformin Hydrochloride, Phenethylbiguanide, Phenethylbiguanide hydrochloride, Phenethylbiguanide Hydrochloride, PotassiumChannel, Potassium Channel, Inhibitor, inhibit, AMP-activated protein kinase, AMPK, Autophagy

Compound Identifiers

PubChem CID

13266