Phenamil methanesulfonate

SKU: orb3177596

Description

Phenamil methanesulfonate is a potent analog of Amiloride that functions as a strong and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM, Phenamil methanesulfonate also acts as a competitive inhibitor of TRPP3 and suppressing TRPP3-mediated calcium transport with an IC50 of 140 nM in Ca2+ uptake assays. Phenamil methanesulfonate robustly activates BMP signaling to promote bone repair, supporting its use in cystic fibrosis lung disease, ion channel biology, and regenerative medicine research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1161-94-0
• MW: 401.83
• Purity: 98.33% (May vary between batches)
• Formula: C₁₃H₁₆ClN₇O₄S
• SMILES: O=C(NC(=N)NC=1C=CC=CC1)C2=NC(Cl)=C(N=C2N)N.O=S(=O)(O)C
• Target: TRP/TRPV Channel

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TRP/TRPV Channel