Phellodendrine

SKU: orb1300237

Description

Phellodendrine exhibits anti-nephritic properties, potentially through inhibiting macrophage and cytotoxic T lymphocyte proliferation and migration within glomeruli. This small molecule is utilized in immunological and nephrology research, with applications in both in vitro cell-based assays and in vivo models of glomerulonephritis.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Neuroscience, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 6873-13-8
• MW: 342.41
• Purity: 99.94% (May vary between batches)
• Formula: C₂₀H₂₄NO₄
• SMILES: C[N@+]12[C@](C=3C(CC1)=CC(OC)=C(O)C3)(CC=4C(C2)=CC(OC)=C(O)C4)[H]
• Target: Interleukin,MMP,ROS,Akt,PKC,mTOR,STAT,AMPK,PI3K,COX,p38 MAPK,NF-κB,Apoptosis,Autophagy
• Solubility: H2O:34.2 mg/mL (99.88 mM);Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble;DMSO:91.67 mg/mL (267.72 mM)

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nuclear factor-κB, Nuclear factor-kappaB, NF-κB, NFkB, NF-kB, NFκB, inhibit, Inhibitor, Akt, PKB, Phallodendrin, Phellodendrine, Protein kinase B

Compound Identifiers

PubChem CID

3081405