Phe-PEG1-Dasa

SKU: orb3177227

Description

Phe-PEG1-Dasa is a BCR-ABL PROTAC degrader with a DC50 of 1.56 nM. It employs a single amino acid (Phe) as an E3 ligase ligand, leveraging the N-end rule pathway to induce target protein degradation, thereby significantly reducing its molecular size, earning the name mini-PROTAC. Phe-PEG1-Dasa markedly inhibits the proliferation of K562 cells and is applicable in leukemia research.

Key Properties

• CAS Number: 3037776-73-8
• MW: 750.32
• Formula: C₃₆H₄₄ClN₉O₅S
• SMILES: N(C1=CC(N2CCN(CCOC(CCOCCNC([C@H](CC3=CC=CC=C3)N)=O)=O)CC2)=NC(C)=N1)C=4SC(C(NC5=C(C)C=CC=C5Cl)=O)=CN4
• Target: PROTACs,Bcr-Abl

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PROTACs,Bcr-Abl