Phe-Lys(Trt)-PAB

SKU: orb1307319

Description

Phe-Lys(Trt)-PAB is a cathepsin-cleavable linker used in ADC research. It enables targeted drug release in lysosomes, a mechanism validated in both in vitro cytotoxicity assays and in vivo xenograft models for cancer therapy development.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1116085-99-4
• MW: 640.81
• Purity: 99.68% (May vary between batches)
• Formula: C₄₁H₄₄N₄O₃
• SMILES: OCC(C=C1)=CC=C1NC([C@@H](NC([C@@H](N)CC2=CC=CC=C2)=O)CCCCNC(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O
• Target: PROTAC Linker,ADC Linker

Bioactivity

• In Vitro:
  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ADC Linkers, ADC Linker, ADCLinker, Antibody-drug conjugates linkers, Cleavable, inhibit, Inhibitor, Phe-Lys(Trt)-PAB, PheLys(Trt)PAB, Phe Lys(Trt) PAB

Compound Identifiers

PubChem CID

135393461