PHD-IN-1

SKU: orb2277674

Description

PHD-IN-1 (compound 80) is a highly potent PHD2 inhibitor with an IC50 of ≤5 nM. It induces EPO expression with an EC50 of 2.5 μM in cellular assays, as demonstrated in Caco2 and Hep3B cell lines. This inhibitor is a valuable chemical probe for researching hypoxia signaling pathways in both cellular and animal models of HIF stabilization.

Research Area

Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 2924182-31-8
• MW: 441.49
• Formula: C₂₄H₂₃N₇O₂
• SMILES: OC=1C2=C(N=C(N3[C@@]4(CN([C@](C3)(C4)[H])C5CC5)[H])C=C2)C=NC1C(NCC=6C=CC(C#N)=NC6)=O
• Target: HIF/HIF Prolyl-Hydroxylase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168510619