PHD-1-IN-1

SKU: orb1297970

Description

PHD-1-IN-1 is a highly potent and selective inhibitor of the HIF prolyl hydroxylase domain 1 (PHD1) enzyme, demonstrating an IC50 of 34 nM. This compound is a valuable chemical tool for investigating hypoxia signaling pathways and has been utilized in both cellular and animal models to study ischemic and inflammatory conditions.

Research Area

Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 2009343-14-8
• MW: 220.23
• Purity: 99.78% (May vary between batches)
• Formula: C₁₃H₈N₄
• SMILES: N#Cc1ccc(cc1)-c1cccc2ncnn12
• Target: HIF/HIF Prolyl-Hydroxylase
• Solubility: DMSO:11 mg/mL (49.95 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:8 mg/mL (36.33 mM)

Bioactivity

• Target IC50:
  PHD1:0.034 μM
• In Vivo:
  Administration of PHD-1-IN-1 (3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng h/mL, Kp,uu of 1.11 and B/P of 0.95.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

active, Arg367-out, Inhibitor, HIF, HIF ProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, HIFProlylHydroxylase, HIF-PH, HIFs, Hypoxia-inducible factors, Fe2+, inhibit, ion, iron, pocket, orally, PHD 1 IN 1, PHD1, PHD-1, PHD1IN1, PHD-1-IN-1, site

Compound Identifiers

PubChem CID

122540724