Phaclofen

SKU: orb1704235

Description

Phaclofen is a selective GABAB receptor antagonist used in neuroscience research. It reverses the inhibitory effects of baclofen and GABA on cholinergic contractions in isolated guinea pig ileum and colon preparations, making it a valuable tool for studying GABAergic signaling in vitro.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 114012-12-3
• MW: 249.63
• Purity: 99.32% (May vary between batches)
• Formula: C₉H₁₃ClNO₃P
• SMILES: O=P(O)(O)CC(C1=CC=C(Cl)C=C1)CN
• Target: GABA Receptor
• Solubility: 1eq. NaOH:<6.24 mg/mL;H2O:30 mg/mL (120.18 mM);DMSO:< 1 mg/mL (23.90 mM)

Bioactivity

• In Vivo:
  In Sprague-Dawley rats (180-250 g), Phaclofen (2 mg/kg; intraperitoneal injection) reduced the number of neuropeptide Y-like immunoreactive fibers in the stimulated cuneate nucleus.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-Amino-2-(4-chlorophenyl)propanephosphonic acid, GABA Receptor, GABAReceptor, Phaclofen

Compound Identifiers

PubChem CID

1641