PHA-680626

SKU: orb1740184

Description

PHA-680626 is a potent, selective PLK inhibitor with additional activity against Bcr-Abl and Aurora kinases. It demonstrates anti-proliferative and pro-apoptotic effects in Imatinib-resistant CML models, including cell lines and primary CD34+ cells, supporting its research use in oncology and kinase signaling pathways.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 398493-74-8
• MW: 450.56
• Formula: C₂₃H₂₆N₆O₂S
• SMILES: N(C(=O)C1=CC=C(C=C1)N2CCN(C)CC2)C=3C4=C(CN(C(CC5=CC=CS5)=O)C4)NN3
• Target: Aurora Kinase,Apoptosis,Others,Histone Methyltransferase,Bcr-Abl,c-Myc

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11751305